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      Diltiazem and mibefradil increase the plasma concentrations and greatly enhance the adrenal-suppressant effect of oral methylprednisolone.

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          Abstract

          To examine the possible interaction of the calcium channel blockers diltiazem and mibefradil with orally administered methylprednisolone.

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          Author and article information

          Journal
          Clin. Pharmacol. Ther.
          Clinical pharmacology and therapeutics
          Elsevier BV
          0009-9236
          0009-9236
          Mar 2000
          : 67
          : 3
          Affiliations
          [1 ] Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Finland.
          S0009-9236(00)42071-0
          10.1067/mcp.2000.104611
          10741623

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