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      Penetration of Titanium Dioxide Microparticles in a Sunscreen Formulation into the Horny Layer and the Follicular Orifice


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          Coated titanium dioxide (TiO<sub>2</sub>) microparticles are commonly used as UV filter substances in commercial sunscreen products. The penetration of these microparticles into the horny layer and the orifice of the hair follicle was investigated. The distribution of the microparticles in the horny layer was analyzed using the method of tape stripping in combination with spectroscopic measurements. Deeper layers of the stratum corneum were devoid of TiO<sub>2</sub> even after repetitive application of sunscreen preparation when analyzing interfollicular areas. Only in the areas of the pilosebaceous orifices could microparticles be identified. The penetration of TiO<sub>2</sub> was investigated in histological skin sections. A biopsy was taken from a skin area from which the horny layer had been removed by tape stripping. In isolated areas, a penetration of coated TiO<sub>2</sub> into the open part of the follicle was observed. The amount of TiO<sub>2</sub> found in a given follicle was less than 1% of the applied total amount of sunscreens. A penetration of microparticles into viable skin tissue could not be detected.

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          An Unexpected Finding in Percutaneous Absorption Observed between Haired and Hairless Guinea Pig Skin


            Author and article information

            Skin Pharmacol Physiol
            Skin Pharmacology and Physiology
            S. Karger AG
            October 1999
            16 August 1999
            : 12
            : 5
            : 247-256
            aDermatological Clinic, Medical Faculty Charité, Humboldt University Berlin, bLaser and Medicine Technology GmbH Berlin, Germany; cL’Oréal, Paris, France
            66249 Skin Pharmacol Appl Skin Physiol 1999;12:247–256
            © 1999 S. Karger AG, Basel

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            Page count
            Figures: 6, Tables: 1, References: 9, Pages: 10
            Original Research Article

            Oncology & Radiotherapy,Pathology,Surgery,Dermatology,Pharmacology & Pharmaceutical medicine
            Biopsy,Penetration,Tape stripping,Follicle,X-ray fluorescence,Ultraviolet/visible spectroscopy,Laser scanning microscopy,Raman spectroscopy


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