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      Penetration of Titanium Dioxide Microparticles in a Sunscreen Formulation into the Horny Layer and the Follicular Orifice

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          Abstract

          Coated titanium dioxide (TiO<sub>2</sub>) microparticles are commonly used as UV filter substances in commercial sunscreen products. The penetration of these microparticles into the horny layer and the orifice of the hair follicle was investigated. The distribution of the microparticles in the horny layer was analyzed using the method of tape stripping in combination with spectroscopic measurements. Deeper layers of the stratum corneum were devoid of TiO<sub>2</sub> even after repetitive application of sunscreen preparation when analyzing interfollicular areas. Only in the areas of the pilosebaceous orifices could microparticles be identified. The penetration of TiO<sub>2</sub> was investigated in histological skin sections. A biopsy was taken from a skin area from which the horny layer had been removed by tape stripping. In isolated areas, a penetration of coated TiO<sub>2</sub> into the open part of the follicle was observed. The amount of TiO<sub>2</sub> found in a given follicle was less than 1% of the applied total amount of sunscreens. A penetration of microparticles into viable skin tissue could not be detected.

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          An Unexpected Finding in Percutaneous Absorption Observed between Haired and Hairless Guinea Pig Skin

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            Author and article information

            Journal
            SPH
            Skin Pharmacol Physiol
            10.1159/issn.1660-5527
            Skin Pharmacology and Physiology
            S. Karger AG
            1660-5527
            1660-5535
            1999
            October 1999
            16 August 1999
            : 12
            : 5
            : 247-256
            Affiliations
            aDermatological Clinic, Medical Faculty Charité, Humboldt University Berlin, bLaser and Medicine Technology GmbH Berlin, Germany; cL’Oréal, Paris, France
            Article
            66249 Skin Pharmacol Appl Skin Physiol 1999;12:247–256
            10.1159/000066249
            10461093
            6dbef25b-7448-49ac-9b15-b197bd6294b8
            © 1999 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            Figures: 6, Tables: 1, References: 9, Pages: 10
            Categories
            Original Research Article

            Oncology & Radiotherapy,Pathology,Surgery,Dermatology,Pharmacology & Pharmaceutical medicine
            Biopsy,Penetration,Tape stripping,Follicle,X-ray fluorescence,Ultraviolet/visible spectroscopy,Laser scanning microscopy,Raman spectroscopy

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