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      Immunoelectron Microscopic Localization of Fibrin-Related Antigen in Human Glomerular Diseases

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          Abstract

          The distribution of fibrin-related antigen (FRA) in glomeruli was examined by immunoelectron microscopy in 9 patients with idiopathic membranous nephropathy (MN), 8 patients with minimal-change nephrotic syndrome, and 10 patients with IgA nephropathy (IgA-N), using antisera against human γ-chain, α-chain, μ-chain, and fibrinogen. Electron-dense reaction products of FRA were observed in the endothelium, subendothelium, and/or in electron-dense deposits (EDD). Among the three glomerular diseases, the amount of electron-dense reaction products of FRA in the endothelium was highest in MN. This suggests that coagulation occurs on the endothelium in MN. Although the mesangial EDD of IgA-N were intensely stained with reaction products of FRA, the staining was weak in the subepithelial EDD of MN. This suggests that FRA hardly penetrates into the subepithelial EDD in MN.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1989
          1989
          10 December 2008
          : 52
          : 3
          : 238-243
          Affiliations
          Department of Internal Medicine, Amagasaki Hospital, Amagasaki; Department of Internal Medicine, Himeji National Hospital, Himeji; Second Department of Pathology and Third Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan
          Article
          185649 Nephron 1989;52:238–243
          10.1159/000185649
          2662049
          © 1989 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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