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      Occupational exposure to asbestos and risk of kidney cancer: an updated meta-analysis


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          Limited information is available on carcinogenicity of asbestos on non-respiratory organs. We aimed at conducted an updated systematic review and meta-analysis of cohort studies on occupational exposure to asbestos and risk of kidney cancer. We searched through three databases, PubMed, Embase and Scopus for article published after 2000, and after eliminating duplicates and non-relevant studies, we identified 13 studies. We combined their results with those of 31 non-overlapping studies included in a previous review up to 2000. We conducted a meta-analysis based on random-effects models. The pooled relative risk of kidney cancer for asbestos exposure was 0.94 (95% confidence interval, 0.84–1.04), with no differences according to type of asbestos fiber, geographic region, period of exposure, or estimated quality of the study. Our results showed a lack of association between occupational asbestos exposure and risk of kidney cancer.

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s10654-021-00769-x.

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          Most cited references62

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          Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

          This article provides a status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions. There will be an estimated 18.1 million new cancer cases (17.0 million excluding nonmelanoma skin cancer) and 9.6 million cancer deaths (9.5 million excluding nonmelanoma skin cancer) in 2018. In both sexes combined, lung cancer is the most commonly diagnosed cancer (11.6% of the total cases) and the leading cause of cancer death (18.4% of the total cancer deaths), closely followed by female breast cancer (11.6%), prostate cancer (7.1%), and colorectal cancer (6.1%) for incidence and colorectal cancer (9.2%), stomach cancer (8.2%), and liver cancer (8.2%) for mortality. Lung cancer is the most frequent cancer and the leading cause of cancer death among males, followed by prostate and colorectal cancer (for incidence) and liver and stomach cancer (for mortality). Among females, breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death, followed by colorectal and lung cancer (for incidence), and vice versa (for mortality); cervical cancer ranks fourth for both incidence and mortality. The most frequently diagnosed cancer and the leading cause of cancer death, however, substantially vary across countries and within each country depending on the degree of economic development and associated social and life style factors. It is noteworthy that high-quality cancer registry data, the basis for planning and implementing evidence-based cancer control programs, are not available in most low- and middle-income countries. The Global Initiative for Cancer Registry Development is an international partnership that supports better estimation, as well as the collection and use of local data, to prioritize and evaluate national cancer control efforts. CA: A Cancer Journal for Clinicians 2018;0:1-31. © 2018 American Cancer Society.
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            Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

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              Bias in meta-analysis detected by a simple, graphical test


                Author and article information

                Eur J Epidemiol
                Eur J Epidemiol
                European Journal of Epidemiology
                Springer Netherlands (Dordrecht )
                30 June 2021
                30 June 2021
                : 36
                : 9
                : 927-936
                [1 ]GRID grid.6292.f, ISNI 0000 0004 1757 1758, Department of Medical and Surgical Sciences, , University of Bologna, ; Bologna, Italy
                [2 ]GRID grid.7605.4, ISNI 0000 0001 2336 6580, Department of Public Health and Pediatric Sciences, , University of Turin, ; Turin, Italy
                [3 ]GRID grid.36425.36, ISNI 0000 0001 2216 9681, Stony Brook Cancer Center, , Stony Brook University, ; Lauterbur Dr, Stony Brook, NY 11794 USA
                Author information
                © The Author(s) 2021

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                : 5 February 2021
                : 28 May 2021
                Funded by: Alma Mater Studiorum - Università di Bologna
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                © Springer Nature B.V. 2021

                Public health
                asbestos,kidney cancer,occupational exposure,meta-analysis
                Public health
                asbestos, kidney cancer, occupational exposure, meta-analysis


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