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      Stimuli-responsive nanotherapeutics for precision drug delivery and cancer therapy

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          Cancer genes and the pathways they control.

          The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation.
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            The future of peptide-based drugs.

            The suite of currently used drugs can be divided into two categories - traditional 'small molecule' drugs with typical molecular weights of 5000 Da that are not orally bioavailable and need to be delivered via injection. Due to their small size, conventional small molecule drugs may suffer from reduced target selectivity that often ultimately manifests in human side-effects, whereas protein therapeutics tend to be exquisitely specific for their targets due to many more interactions with them, but this comes at a cost of low bioavailability, poor membrane permeability, and metabolic instability. The time has now come to reinvestigate new drug leads that fit between these two molecular weight extremes, with the goal of combining advantages of small molecules (cost, conformational restriction, membrane permeability, metabolic stability, oral bioavailability) with those of proteins (natural components, target specificity, high potency). This article uses selected examples of peptides to highlight the importance of peptide drugs, some potential new opportunities for their exploitation, and some difficult challenges ahead in this field. © 2012 John Wiley & Sons A/S.
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              A New Property of MCM-41:  Drug Delivery System

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                Author and article information

                Journal
                Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
                WIREs Nanomed Nanobiotechnol
                Wiley
                19395116
                January 2019
                January 2019
                May 04 2018
                : 11
                : 1
                : e1527
                Affiliations
                [1 ]The First Affiliated Hospital; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine; Zhejiang University; Hangzhou P.R. China
                [2 ]Department of Chemical Engineering; Zhejiang University; Hangzhou P.R. China
                [3 ]School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening; Southern Medical University; Guangzhou P.R. China
                Article
                10.1002/wnan.1527
                29726115
                6dd57aed-08e6-455e-bddd-382dfb01cb68
                © 2018

                http://doi.wiley.com/10.1002/tdm_license_1.1

                http://onlinelibrary.wiley.com/termsAndConditions#vor

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