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      Evaluation of the Growth-Hormone-Releasing Hormone Test in Short Normal and Growth-Hormone-Deficient Children

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          Growth-hormone-releasing hormone (GHRH) tests were performed once [GHRH(1–29)NH<sub>2</sub>, 1 µg/kg] or on 2 consecutive days [GHRH(1–44)NH<sub>2</sub>, 1 and 2 µg/kg administered in random order] in 27 children with idiopathic, isolated growth hormone (GH)-deficiency and in 49 short normal children, all clinically prepubertal. No differences in GH release were found between the tests performed on the 1 st and 2nd day or according to GHRH dose or sex, both in GH-deficient and control children. 80% of GH-deficient and 87% of control children responded (GH peak > IO ng/ml) to GHRH(1–29)NH<sub>2</sub>, and 65% of GH-deficient and all control children to GHRH(1-44)NH<sub>2</sub>· No differences in GH release were found between GH-deficient GHRH responders and control children. 17% of GH-deficient and 10% of control children responded only to one of the two tests performed on 2 consecutive days; the lack of responsiveness was unrelated to GHRH dose and sequence of GHRH administration (1st or 2nd day). The GHRH test does not seem to be a reproducible test for the evaluation of GH release, nor is it useful to differentiate GH-deficient GHRH responders from short normal children.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 34
          : 1
          : 13-16
          aInstitute of Clinical and Preventive Pediatrics, University of Bari; bDepartment of Pediatrics, University of Messina, Italy
          181788 Horm Res 1990;34:13–16
          © 1990 S. Karger AG, Basel

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          Pages: 4
          Original Paper


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