Research in paediatric nursing, paediatric psychology, health care management and environment-behaviour studies suggest that there are many obstacles in completing qualitative research in health care settings with children and young people. As a result, the evidence from this kind of research is limited. Both authors have recently completed participatory qualitative studies with children and young people in paediatric environments, both in Malaysia and Australia. These will be briefly described and some of the practical and methodological challenges that each researcher experienced will be discussed. Each challenge has strong implications and potential impact on the research quality; and also on the children and young people’s experience of research. Keywords: qualitative, children, health care, research eISSN 2514-751X © 2017 The Authors. Published for AMER ABRA by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.