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Abstract
Fifteen new lupane-type triterpenoids (1-15) and 10 known triterpenoids (16-25) were
isolated from the stems of Euonymus carnosus. The structures of the new compounds
were elucidated on the basis of spectroscopic analyses, and the absolute configuration
of compound 1 was confirmed by X-ray crystallographic analysis using anomalous scattering
of Cu Kα radiation. In addition, the compounds were tested for their cytotoxic activity
against five human cancer cell lines and their ability to inhibit LPS-induced nitric
oxide production in the murine microglia BV2 cell line. Compound 11 exhibited moderate
cytotoxicity against several human cancer cell lines, and compounds 1, 2, 4, 5, 20,
and 25 showed neuritis inhibitory activity against microglial inflammation factor,
with IC50 values of 7.39, 7.48, 7.80, 3.48, 2.54, and 6.09 μM, respectively.
[1
]State Key Laboratory of Bioactive Substance and Function
of Natural Medicines, Institute
of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,
Beijing 100050, People’s Republic of China