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      Worsening renal function during renin-angiotensin-aldosterone system inhibitor initiation and long-term outcomes in patients with left ventricular systolic dysfunction.

      European Journal of Heart Failure
      Wiley
      Angiotensin receptor blocker, Heart failure, Mineralocorticoid receptor antagonists, RAAS inhibitors, Renal impairment, Worsening renal function

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          Abstract

          Impaired renal function is associated with worse clinical outcomes in patients with LV systolic dysfunction (LVSD) and heart failure. Renin-angiotensin-aldosterone system (RAAS) inhibitors provide clinical benefit in these settings and often worsen renal function. It is not clear whether worsening renal function (WRF) in patients exposed to these agents predicts a worse prognosis or merely reflects the pharmacological action of the drug on the kidney.

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