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      De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation.

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          Abstract

          The development of human leukocyte antigen (HLA) antibody responses has been associated with worse clinical outcomes, such as bronchiolitis obliterans syndrome (BOS) and death, in lung transplant recipients (LTRs). However, the role of donor-specific HLA antibody (DSA) responses as a risk factor for poor outcomes remains controversial.

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          Author and article information

          Journal
          J. Heart Lung Transplant.
          The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
          1557-3117
          1053-2498
          Dec 2014
          : 33
          : 12
          Affiliations
          [1 ] Division of Pulmonary Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: morrellmr@upmc.edu.
          [2 ] Division of Pulmonary Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
          [3 ] Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania.
          [4 ] Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.
          [5 ] Division of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
          Article
          S1053-2498(14)01285-6
          10.1016/j.healun.2014.07.018
          25443870
          6e07ed9d-b530-4d93-8393-2366b504c777
          Copyright © 2014 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
          History

          bronchiolitis obliterans syndrome,death,donor-specific antibody,human leukocyte antigen,lung transplant

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