Beta-Endorphin, Beta-Lipotropin and Adrenocorticotropic Hormone Levels in Cerebrospinal Fluid, and Brain Damage in Chronic Alcoholics

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Abstract

In 34 chronic alcoholics, subdivided into two groups according to the state of the blood-brain barrier (BBB), β-lipotropin (β-LPH), β-endorphin (β-EP), ACTH and Cortisol levels were determined in basal conditions in the plasma and cerebrospinal fluid (CSF). Hormonal concentrations were correlated with brain damage and mnesic function. The results indicate the reduced CSF β-EP content in chronic alcoholics and suggest that peripheral β-EP may penetrate into the CSF compartment when there is BBB damage. They also sustain the different origins of central and peripheral pro-opiocortin-related peptides, and support the concept that β-EP, β-LPH and ACTH may be autonomously regulated at the central level. Moreover, both morphological brain damage and mnesic impairment in chronic alcoholics are unrelated to CSF peptide levels. The role of opioid peptides in the nature of alcohol-seeking behavior is supported.

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Author and article information

Journal

Journal ID (publisher-id): ENE

Journal ID (nlm-ta): Eur Neurol

Journal ID (doi): 10.1159/issn.0014-3022

Title: European Neurology

Publisher: S. Karger AG

ISSN (Print): 0014-3022

ISSN (Electronic): 1421-9913

Publication date Subscription-year: 1983

Publication date (Print): 1983

Publication date (Electronic): 31 January 2008

Volume: 22

Issue: 4

Pages: 265-271

Affiliations

^aDepartment of Neurology, University of Pavia, Italy; ^bDepartment of Obstetrics and Gynecology, University of Modena, Italy, and ^cDepartment of Obstetrics and Gynecology, University of Siena, Italy

Article

Publisher ID: 115570 Other ID: Eur Neurol 1983;22:265–271

DOI: 10.1159/000115570

PubMed ID: 6309526

SO-VID: 6e08702c-3492-4177-b580-96b55b2393bb

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 01 November 1982

Date accepted : 20 January 1983

Page count

Pages: 7

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