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      On the medicinal chemistry of gold complexes as anticancer drugs

      Coordination Chemistry Reviews
      Elsevier BV

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          Platinum Compounds: a New Class of Potent Antitumour Agents

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            New trends for metal complexes with anticancer activity.

            Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design of new drugs. This has, for instance, led to the clinical application of chemotherapeutic agents for cancer treatment, such as cisplatin. The use of cisplatin is, however, severely limited by its toxic side-effects. This has spurred chemists to employ different strategies in the development of new metal-based anticancer agents with different mechanisms of action. Recent trends in the field are discussed in this review. These include the more selective delivery and/or activation of cisplatin-related prodrugs and the discovery of new non-covalent interactions with the classical target, DNA. The use of the metal as scaffold rather than reactive centre and the departure from the cisplatin paradigm of activity towards a more targeted, cancer cell-specific approach, a major trend, are discussed as well. All this, together with the observation that some of the new drugs are organometallic complexes, illustrates that exciting times lie ahead for those interested in 'metals in medicine'.
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              Gold-based therapeutic agents.

              C. E. Shaw (1999)
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                Author and article information

                Journal
                Coordination Chemistry Reviews
                Coordination Chemistry Reviews
                Elsevier BV
                00108545
                June 2009
                June 2009
                : 253
                : 11-12
                : 1670-1681
                Article
                10.1016/j.ccr.2009.02.019
                6e0a9b29-e8dc-4d25-8cad-0f1830358645
                © 2009

                http://www.elsevier.com/tdm/userlicense/1.0/

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