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      Photothermal-Responsive Conjugated Polymer Nanoparticles for Remote Control of Gene Expression in Living Cells

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          A clearer vision for in vivo imaging.

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            ReaChR: A red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation

            Channelrhodopsins are used to optogenetically depolarize neurons. We engineered a variant of channelrhodopsin, denoted Re d- a ctivatable Ch annel r hodopsin (ReaChR), that is optimally excited with orange to red light (λ ~ 590 to 630 nm) and offers improved membrane trafficking, higher photocurrents, and faster kinetics compared with existing red-shifted channelrhodopsins. Red light is more weakly scattered by tissue and absorbed less by blood than the blue to green wavelengths required by other channelrhodopsin variants. ReaChR expressed in vibrissa motor cortex was used to drive spiking and vibrissa motion in awake mice when excited with red light through intact skull. Precise vibrissa movements were evoked by expressing ReaChR in the facial motor nucleus in the brainstem and illuminating with red light through the external auditory canal. Thus, ReaChR enables transcranial optical activation of neurons in deep brain structures without the need to surgically thin the skull, form a transcranial window, or implant optical fibers.
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              Optogenetics.

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                Author and article information

                Journal
                Advanced Materials
                Adv. Mater.
                Wiley
                09359648
                February 2018
                February 2018
                January 12 2018
                : 30
                : 8
                : 1705418
                Affiliations
                [1 ]School of Chemistry and Chemical Engineering; Shanxi University; Taiyuan 030006 P. R. China
                [2 ]Beijing National Laboratory for Molecular Sciences; Key Laboratory of Organic Solids; Institute of Chemistry; Chinese Academy of Sciences; Beijing 100190 P. R. China
                Article
                10.1002/adma.201705418
                6e1ad14a-d145-43d3-a135-2fdf75611d9f
                © 2018

                http://doi.wiley.com/10.1002/tdm_license_1.1

                http://onlinelibrary.wiley.com/termsAndConditions#vor

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