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      Effects of a Low-Protein Diet on Urinary Glycosaminoglycan Excretion in Adriamycin-Treated Rats

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          Adriamycin (ADR) induces glomerular damage in rats with persistent severe proteinuria which reaches a peak 15 days after a single 5 mg/kg intravenous (i.v.) injection. We studied in ADR-treated rats the effects of a low-protein (6%) diet (LPD) supplemented with keto acids on urinary protein and glycosaminoglycan (GAG) excretion and glomerular GAG contents. Animals were divided into three groups: group 1 was used as control, and groups 2 and 3 received a single i.v. injection of ADR; group 2 was fed a standard diet (21% protein) and group 3 an LPD. After ADR, group 2 developed heavy proteinuria and showed a progressive increase in urinary GAG excretion starting a few days after the beginning of proteinuria onset and persisting throughout the experiment. After ADR, group 3 (LPD treatment) did not develop proteinuria, and the level of urinary GAGs was comparable to that of controls. The glomerular GAG level in ADR-treated rats was greatly reduced as compared to controls; this decrease was partly eliminated in rats on an LPD. These results suggest that an LPD has a direct effect on cellular GAG production and turnover in ADR-induced glomerulonephritis.

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          Author and article information

          S. Karger AG
          12 December 2008
          : 64
          : 2
          : 242-248
          aGroupe d’Etude de Physiologie et Physiopathologie Rénales, Faculté de Pharmacie, et bService de Clinique Néphrologique, Hôpital Pellegrin, Place Amélie Raba-Léon, Bordeaux, France
          187321 Nephron 1993;64:242–248
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 7
          Original Paper

          Cardiovascular Medicine, Nephrology

          Glycosaminoglycans, Proteinuira, Adriamycin, Rats, Low-protein diet


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