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      G₀/G 1 Arrest of Cell Proliferation in the Ocular Lens Prevents Development of Radiation Cataract

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          Abstract

          Exposure of the eyes of young frogs and rats to X-rays (12–25 Gy) causes posterior cataracts to appear several weeks later. Hypophysectomized frogs do not develop these opacities, but hypophysectomized rats do. In the former, but not the latter animals, the operation completely stops lens mitosis, the epithelial cells being largely confined to the G₀/ G<sub>1</sub> phase of the cell cycle.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1982
          1982
          04 December 2009
          : 14
          : 3
          : 215-220
          Affiliations
          Fordham ., University, Department of Biological Science, Bronx, N.Y., U.S.A.; College of Physicians and Surgeons of Columbia University Ocular Radiation Research Laboratory, Department of Ophthalmology, New York, N.Y., USA
          Article
          265195 Ophthalmic Res 1982;14:215–220
          10.1159/000265195
          6980388
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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