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      Gut microbiota, metabolites and host immunity

      research-article
      1 , 1 , 2 , 3 , 4
      Nature reviews. Immunology

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          Abstract

          The microbiota — the collection of microorganisms that live within and on all mammals — provides crucial signals for the development and function of the immune system. Increased availability of technologies that profile microbial communities is facilitating the entry of many immunologists into the evolving field of host-microbiota studies. The microbial communities, their metabolites and components are not only necessary for immune homeostasis, they also influence the susceptibility of the host to many immune-mediated diseases and disorders. In this Review, we discuss technological and computational approaches for investigating the microbiome, as well as recent advances in our understanding of host immunity and microbial mutualism with a focus on specific microbial metabolites, bacterial components and the immune system.

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          Author and article information

          Journal
          101124169
          27017
          Nat Rev Immunol
          Nat. Rev. Immunol.
          Nature reviews. Immunology
          1474-1733
          1474-1741
          9 June 2017
          27 May 2016
          03 August 2017
          : 16
          : 6
          : 341-352
          Affiliations
          [1 ]Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
          [2 ]Harvard Medical School, Boston, Massachusetts 02115, USA.
          [3 ]Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
          [4 ]Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
          Author notes
          Correspondence to W.S.G. wgarrett@ 123456hsph.harvard.edu
          Article
          PMC5541232 PMC5541232 5541232 nihpa882996
          10.1038/nri.2016.42
          5541232
          27231050
          6e3fa9c9-9c66-4ede-abdf-e5cfefd924f0
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