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      Co-delivery of a RanGTP inhibitory peptide and doxorubicin using dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer cells.

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          Abstract

          Multidrug resistance (MDR) limits the beneficial outcomes of conventional breast cancer chemotherapy. Ras-related nuclear protein (Ran-GTP) plays a key role in these resistance mechanisms, assisting cancer cells to repair damage to DNA. Herein, we investigate the co-delivery of Ran-RCC1 inhibitory peptide (RAN-IP) and doxorubicin (DOX) to breast cancer cells using liposomal nanocarriers.

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          Author and article information

          Journal
          Expert Opin Drug Deliv
          Expert opinion on drug delivery
          Informa UK Limited
          1744-7593
          1742-5247
          November 2020
          : 17
          : 11
          Affiliations
          [1 ] Department of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University , Tanta, Egypt.
          [2 ] School of Pharmacy and Clinical Sciences, University of Bradford , Bradford, UK.
          [3 ] School of Pharmacy and Pharmaceutical Sciences, Ulster University , UK.
          [4 ] Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University , Amman, Jordan.
          [5 ] Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford , Bradford, UK.
          Article
          10.1080/17425247.2020.1813714
          32841584
          6e41d2cf-d85d-4217-b2ea-f23b0be9510a
          History

          optimization,ran-inhibitory peptide,Doxorubicin,breast cancer,drug delivery,formulation variables,liposome

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