Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.

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Abstract

The genetic differences between human papilloma virus (HPV)-positive and -negative head and neck squamous cell carcinomas (HNSCC) remain largely unknown. To identify differential biology and novel therapeutic targets for both entities, we determined mutations and copy-number aberrations in a large cohort of locoregionally advanced HNSCC.

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Journal

Journal ID (iso-abbrev): Clin. Cancer Res.

Title: Clinical cancer research : an official journal of the American Association for Cancer Research

ISSN: 1078-0432

ISSN (Print): 1078-0432

Publication date (Electronic): Feb 1 2015

Volume: 21

Issue: 3

Affiliations

[1 ] Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois. The University of Chicago Comprehensive Cancer Center, Chicago, Illinois. Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois. tseiwert@medicine.bsd.uchicago.edu.

[2 ] Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois.

[3 ] Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.

[4 ] Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee.

[5 ] Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania.

[6 ] Broad Institute of Harvard and MIT, Cambridge, Massachusetts.

[7 ] The University of Chicago Comprehensive Cancer Center, Chicago, Illinois. Department of Radiation Oncology, The University of Chicago, Chicago, Illinois.

[8 ] The University of Chicago Comprehensive Cancer Center, Chicago, Illinois. Department of Otolaryngology/Head and Neck Surgery, The University of Chicago, Chicago, Illinois.

[9 ] The University of Chicago Comprehensive Cancer Center, Chicago, Illinois. Department of Pathology, University of Chicago, Chicago, Illinois.

[10 ] Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois. The University of Chicago Comprehensive Cancer Center, Chicago, Illinois.

[11 ] The University of Chicago Comprehensive Cancer Center, Chicago, Illinois. Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois.

Article

Publisher Item ID: 1078-0432.CCR-13-3310 Mid ID: NIHMS616054

DOI: 10.1158/1078-0432.CCR-13-3310

PubMed ID: 25056374

SO-VID: 6e430e7b-fe9b-4d0c-ae4e-b58dce15200a

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