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Abstract
Hollow mesoporous silica (HMS) have been extensively investigated as a biomaterial
for drug delivery. The present study developed quaternary ammonium silane-grafted
hollow mesoporous silica (QHMS) to create a metronidazole (MDZ) sustained delivery
system, MDZ@QHMS, with bimodal, contact-kill and release-kill capability. The QHMS
was assembled through a self-templating method. Metronidazole was incorporated within
the QHMS core using solvent evaporation. Antibacterial activities of the MDZ@QHMS
were investigated using single-species biofilms of Staphylococcus aureus (ATCC25923),
Escherichia coli (ATCC25922) and Porphyromonas gingivalis (ATCC33277). The MDZ@QHMS
maintained a hollow mesoporous structure and demonstrated sustained drug release and
bacteridal actvity against the three bacterial strains at a concentration of 100 μg/mL
or above. These nanoparticles were not relatively cytotoxic to human gingival fibroblasts
when employed below 100 µg/mL. Compared with HMS, the MDZ@QHMS system at the same
concentration demonstrated antibiotic-elution and contact-killing bimodal antibacterial
activities. The synthesized drug carrier with sustained, bimodal antibacterial function
and minimal cytotoxicity possesses potential for localized antibiotic applications.
STATEMENT OF SIGNIFICANCE: The present study develops quaternary ammonium silane-grafted
hollow mesoporous silica (QHMS) to create a metronidazole (MDZ) sustained delivery
system, MDZ@QHMS, with bimodal, contact-kill and release-kill capability. This system
demonstrates sustained drug release and maintained a hollow mesoporous structure.
The synthesized drug carrier with sustained, bimodal antibacterial function and excellent
biocompatibility possesses potential for localized antibiotic applications.