Prognostic value of ERCC1, RRM1, BRCA1 and SETDB1 in early stage of non-small cell lung cancer.

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Abstract

Nowadays, 40 % of early-stage NSCLC patients relapse in the 2 years following resection, suggesting a mis-staging in this group of patients who are not receiving adjuvant chemotherapy. Although different biomarkers, such as ERCC1, RRM1 and BRCA1 have been found to present prognostic value in advanced NSCLC patients, in early-stage NSCLC patients its relevance remains unclear. Moreover, SETDB1 has been recently proposed as a bona fide oncogene in lung tumourigenesis and related with metastasis. The aim of the present study was to analyze the prognostic value of ERCC1, RRM1, BRCA1 and SETDB1 expression levels in NSCLC patients at stage I.

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Journal

Journal ID (iso-abbrev): Clin Transl Oncol

Title: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Publisher: Springer Nature America, Inc

ISSN (Electronic): 1699-3055

ISSN (Print): 1699-048X

Publication date (Electronic): Aug 2016

Volume: 18

Issue: 8

Affiliations

[1 ] Servicio de Genética-Biología Molecular, Hospital Universitario de la Ribera, ctra. Corbera, km.1, 46600, Alzira, Spain. alafuente@hospital-ribera.com.

[2 ] Servicio de Genética-Biología Molecular, Hospital Universitario de la Ribera, ctra. Corbera, km.1, 46600, Alzira, Spain.

[3 ] Servicio de Cirugía Torácica, Hospital Universitario de la Ribera, ctra. Corbera, km.1, 46600, Alzira, Spain.

[4 ] Servicio de Anatomía Patológica, Hospital Universitario de la Ribera, ctra. Corbera, km.1, 46600, Alzira, Spain.

[5 ] Departament de Fisiologia, Facultat de Farmàcia, Universitat de València, Avda. Vicent Andrés Estellés, s/n, 46100, Burjassot, Valencia, Spain.

Article

Publisher Item ID: 10.1007/s12094-015-1440-6

DOI: 10.1007/s12094-015-1440-6

PubMed ID: 26542178

SO-VID: 6e558793-1a5d-4358-9387-8e585312b481

History

Keywords: Prognosis,RRM1,SETDB1,BRCA1,ERCC1,Gene expression,Lung cancer

Data availability:

Keywords: Prognosis, RRM1, SETDB1, BRCA1, ERCC1, Gene expression, Lung cancer

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