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      Immunologic Competence of Hemodialysis Patients following Withdrawal of Vitamin C Supplement

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          Abstract

          Twelve stable nondiabetic patients on chronic hemodialysis were studied for their immunobiologic competence while receiving vitamin C supplement and 1–2 months following its withdrawal. These subjects, on prescribed diets, were checked for their food intake at the beginning of the study and at 1-month intervals thereafter. Immunological parameters tested were: (1) plasma vitamin C levels; (2) number of mononuclear cells isolated from blood and their vitamin C contents; (3) lymphocyte blastogenic response to mitogens; (4) leukocyte metabolic functions in presence of endotoxin by nitroblue tetrazolium reduction test, and (5) delayed hypersensitivity to skin-testing antigens, e.g. Candida and mumps antigens and purified protein derivative. Patients on vitamin C had significantly higher plasma ascorbic acid levels compared to normal healthy subjects. These decreased to low normal levels 1 month following withdrawal of the supplement and stayed comparable thereafter, up to 12 months of the study period. Ascorbic acid contents in the isolated mononuclear cells remained unchanged in patients on or off vitamin C. The number of blood mononuclear cells isolated and mitogenic responses to concanavalin A and phytohemagglutinin did not change following withdrawal of vitamin C supplement. All patients had positive delayed hypersensitivity to Candida, 60% to mumps and all were unresponsive to purified protein derivative. Leukocyte metabolic functions by nitroblue tetrazolium reduction test were higher in patients on vitamin C than when off, but this was not statistically significant. Vitamin C supplement is not necessary in hemodialysis patients when they are on an adequate diet.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1987
          1987
          05 December 2008
          : 47
          : 4
          : 299-304
          Affiliations
          James A. Haley Veterans Hospital, and Department of Internal Medicine University of South Florida, College of Medicine, Tampa, Fla. USA
          Article
          184528 Nephron 1987;47:299–304
          10.1159/000184528
          3696334
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Immunity, Vitamin C, Ascorbic acid, Mononuclear cells, Hemodialysis

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