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      Genetically encoded neural activity indicators

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          Abstract

          Recent years have witnessed the fascinating development of imaging approaches to studying neural activities; this progress has been based on an influx of ideas and methods from molecular biology and optical engineering. Here we review the design and application of genetically encoded indicators for calcium ions, membrane potential and neurotransmitters. We also summarize common strategies for the design and optimization of genetically encoded neural activity indicators.

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          Author and article information

          Contributors
          Journal
          Brain Sci. Adv.
          Brain Science Advances
          Tsinghua University Press and SAGE Publishing
          2096-5958
          25 November 2018
          : 4
          : 1
          : 1-15
          Affiliations
          1School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
          2National Institute of Biological Sciences, Beijing 102206, China
          Author notes
          Address correspondence to Ji Hu, E-mail: huji@ 123456shanghaitech.edu.cn
          Article
          BSA.2018.9050007
          10.26599/BSA.2018.9050007
          © The authors 2018. This article is published with open access at journals.sagepub.com/home/BSA

          This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

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          Self URI (journal page): https://journals.sagepub.com/home/bsa
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