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      Design and analysis of stepped wedge cluster randomized trials.

      1 ,
      Contemporary clinical trials
      Elsevier BV

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          Abstract

          Cluster randomized trials (CRT) are often used to evaluate therapies or interventions in situations where individual randomization is not possible or not desirable for logistic, financial or ethical reasons. While a significant and rapidly growing body of literature exists on CRTs utilizing a "parallel" design (i.e. I clusters randomized to each treatment), only a few examples of CRTs using crossover designs have been described. In this article we discuss the design and analysis of a particular type of crossover CRT - the stepped wedge - and provide an example of its use.

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          Author and article information

          Journal
          Contemp Clin Trials
          Contemporary clinical trials
          Elsevier BV
          1551-7144
          1551-7144
          Feb 2007
          : 28
          : 2
          Affiliations
          [1 ] Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
          Article
          S1551-7144(06)00063-2
          10.1016/j.cct.2006.05.007
          16829207
          6eb75e37-de8d-4848-a560-f30e9e116cd4
          History

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