A theoretical approach for estimating directional changes in the average wave velocity of the systematic vascular bed was found and applied to develop a reliable pressure contour method for determining the ventricular stroke volume following the administration of sympathomimetic agents. Two pressure methods in which the wave velocity was assumed either constant or variable were compared to the electromagnetic flowmeter technique for measuring stroke volume. The overall performance of both pressure methods was essentially the same over a wide range of physiologic conditions in five dogs. Statistical comparison of the pressure methods during interventions with epinephrine and metaraminol demonstrated a significant increase in accuracy when allowance for variations in the pulse wave velocity was made.