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      Is Open Access

      Investigation of the freely available easy-to-use software ‘EZR' for medical statistics

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      1 , *
      Bone Marrow Transplantation
      Nature Publishing Group
      statistical software, EZR, competing risk, time-dependent covariate

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          Abstract

          Although there are many commercially available statistical software packages, only a few implement a competing risk analysis or a proportional hazards regression model with time-dependent covariates, which are necessary in studies on hematopoietic SCT. In addition, most packages are not clinician friendly, as they require that commands be written based on statistical languages. This report describes the statistical software ‘EZR' (Easy R), which is based on R and R commander. EZR enables the application of statistical functions that are frequently used in clinical studies, such as survival analyses, including competing risk analyses and the use of time-dependent covariates, receiver operating characteristics analyses, meta-analyses, sample size calculation and so on, by point-and-click access. EZR is freely available on our website ( http://www.jichi.ac.jp/saitama-sct/SaitamaHP.files/statmed.html) and runs on both Windows (Microsoft Corporation, USA) and Mac OS X (Apple, USA). This report provides instructions for the installation and operation of EZR.

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          Most cited references9

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          A Proportional Hazards Model for the Subdistribution of a Competing Risk

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            A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk

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              Regression modeling of competing risk using R: an in depth guide for clinicians.

              We describe how to conduct a regression analysis for competing risks data. The use of an add-on package for the R statistical software is described, which allows for the estimation of the semiparametric proportional hazards model for the subdistribution of a competing risk analysis as proposed by Fine and Gray. J Am Stat Assoc 1999; 94: 496-509.
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                Author and article information

                Journal
                Bone Marrow Transplant
                Bone Marrow Transplant
                Bone Marrow Transplantation
                Nature Publishing Group
                0268-3369
                1476-5365
                March 2013
                03 December 2012
                : 48
                : 3
                : 452-458
                Affiliations
                [1 ]Division of Hematology, Saitama Medical Center, Jichi Medical University , Saitama, Japan
                Author notes
                [* ]Division of Hematology, Saitama Medical Center, Jichi Medical University , 1-847, Amanuma-cho, Omiya-ku, Saitama-shi, Saitama 330-8503, Japan. E-mail: ycanda-tky@ 123456umin.ac.jp
                Article
                bmt2012244
                10.1038/bmt.2012.244
                3590441
                23208313
                6ebd6293-6349-4054-a4f3-f723f74d9cdf
                Copyright © 2013 Macmillan Publishers Limited

                This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

                History
                : 14 September 2012
                : 31 October 2012
                : 01 November 2012
                Categories
                Technical Report

                Transplantation
                statistical software,ezr,competing risk,time-dependent covariate
                Transplantation
                statistical software, ezr, competing risk, time-dependent covariate

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