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Association of Proton Pump Inhibitors With Reduced Risk of Warfarin-Related Serious Upper Gastrointestinal Bleeding
Wayne A. Ray ,
Cecilia P. Chung ,
Katherine T. Murray ,
Walter E. Smalley ,
James R. Daugherty ,
William D. Dupont ,
C. Michael Stein
December 2016
December 2016
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Abstract
Proton pump inhibitors (PPIs) might reduce the risk of serious warfarin-related upper
gastrointestinal bleeding, but the evidence of their efficacy for this indication
is limited. A gastroprotective effect of PPIs would be particularly important for
patients who take warfarin with antiplatelet drugs or nonselective nonsteroidal anti-inflammatory
drugs (NSAIDs), which further increase the risk of gastrointestinal bleeding.