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      Dopaminergic Binding Sites in Human Pituitary Adenomas Other than Prolactinomas

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          Abstract

          Binding studies of [<sup>3</sup>H]-spiroperidol, a potent dopamine antagonist, were performed on dispersed cells obtained from 2 mixed PRL- and GH-secreting adenomas, 3 GH-secreting adenomas and 4 ‘nonsecreting’ pituitary tumors. Saturable, high affinity binding sites for [<sup>3</sup>H]-spiroperidol were identified in the two adenomas of mixed PRL and GH secretion, in 2 of 3 GH-secreting adenomas and in 2 of 4 ‘nonsecreting’ adenomas. These data indicate that dopaminergic binding sites are present in some GH-secreting adenomas in the absence of PRL hypersecretion and in some ‘nonsecreting’ pituitary adenomas.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1984
          1984
          26 November 2008
          : 19
          : 2
          : 97-102
          Affiliations
          aService of Endocrinology and Service of Neurosurgery, Notre-Dame Hospital and bNeuroendocrine Research Laboratory, Ste-Justine Hospital, University of Montreal, Montreal, Que., Canada
          Article
          179873 Horm Res 1984;19:97–102
          10.1159/000179873
          6706294
          © 1984 S. Karger AG, Basel

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          Page count
          Pages: 6
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