Anwendung von Augentropfen mit Ozon: Eine Fallserie von spontanen Augenerkrankungen bei Tieren und Menschen

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Abstract

Konjunktivitis, Keratokonjunktivitis und Hornhautulzera sind häufige Augenerkrankungen, die sowohl bei Menschen als auch bei Tieren oft diagnostiziert werden; die gängige Behandlung besteht in der topischen Anwendung von Augentropfen mit antiinflammatorischen und antibakteriellen Wirkstoffen. Diese Wirkstoffe sind oft von mangelhafter Wirksamkeit, da Infektionen in hypoxischem Gewebe Methicillin-resistente Staphylococcus aureus und Pseudomonas aeruginosa enthalten; daher werden neue Mittel für die Behandlung von Augenschmerzen und -entzündungen benötigt. Die Anwendung von Ozon (nach Stabilisierung für die topische Applikation in Form eines Ozonids) könnte bei bestimmten Erkrankungen des vorderen Augensegments sowohl wegen seiner entzündungshemmenden und bakteriziden Wirkung als auch durch Förderung der Gewebereparatur von Nutzen sein. Ozonisierte Öle haben die gleichen Eigenschaften wie gasförmiges Ozon und sind dabei gut verträglich für Gewebe. In der vorliegenden Arbeit berichten wir über die Reparatur- und Regenerationseffekte von ozonisiertem Öl in Liposomen plus Hypromellose (Ozodrop®, FB Vision, Ascoli Piceno, Italien) bei 3- bis 4-mal täglicher Instillation zur Behandlung spontaner externer Augenerkrankungen bei Mensch und Tier. Übersetzung aus Case Rep Ophthalmol 2018;9:287-298

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Ozone therapy: A clinical review

A. Elvis, J. Ekta (2011)

Ozone (O3) gas discovered in the mid-nineteenth century is a molecule consisting of three atoms of oxygen in a dynamically unstable structure due to the presence of mesomeric states. Although O3 has dangerous effects, yet researchers believe it has many therapeutic effects. Ozone therapy has been utilized and heavily studied for more than a century. Its effects are proven, consistent, safe and with minimal and preventable side effects. Medical O3 is used to disinfect and treat disease. Mechanism of actions is by inactivation of bacteria, viruses, fungi, yeast and protozoa, stimulation of oxygen metabolism, activation of the immune system. Medication forms in a gaseous state are somewhat unusual, and it is for this reason that special application techniques have had to be developed for the safe use of O3. In local applications as in the treatment of external wounds, its application in the form of a transcutaneous O3 gas bath has established itself as being the most practical and useful method, for example at low (sub-atmospheric) pressure in a closed system guaranteeing no escape of O3 into the surrounding air. Ozonized water, whose use is particularly known in dental medicine, is optimally applied as a spray or compress. Diseases treated are infected wounds, circulatory disorders, geriatric conditions, macular degeneration, viral diseases, rheumatism/arthritis, cancer, SARS and AIDS.

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The dual action of ozone on the skin.

G. Valacchi, Vittoria Fortino, V. Bocci (2005)

The aim of this brief review is to summarize the recent literature on the effect of ozone (O3) on cutaneous tissues. Recently it has been reported that a chronic contact with O3 can be deleterious for the skin. Our group and others have shown a progressive depletion of antioxidant content in the stratum corneum and this can then lead to a cascade of effects resulting in an active cellular response in the deeper layers of the skin. Using an in vivo model we have shown an increase of proliferative, adaptive and proinflammatory cutaneous tissue responses. On the other hand the well known activity of O3 as a potent disinfectant and oxygen (O2) donor has been also studied for therapeutic use. Two approaches have been described. The first consists of a quasi-total body exposure in a thermostatically controlled cabin. This treatment has proved to be useful in patients with chronic limb ischaemia. The second approach is based on the topical application of ozonated olive oil in several kinds of skin infection (from soreness to diabetic ulcers, burns, traumatic and surgical wounds, abscesses and skin reactions after radiotherapy). We and other authors have observed a striking cleansing effect with improved oxygenation and enhanced healing of these conditions. It is now clear that, on the skin, O3, like other drugs, poisons and radiation, can display either a damaging effect from a long exposure or a beneficial effect after a brief exposure to O2 and O3 or to the application of ozonated oil to chronic wounds.

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Therapeutic Effects of Topical Application of Ozone on Acute Cutaneous Wound Healing

Hee Kim, Sun Noh, Ye Han … (2009)

This study was undertaken to evaluate the therapeutic effects of topical ozonated olive oil on acute cutaneous wound healing in a guinea pig model and also to elucidate its therapeutic mechanism. After creating full-thickness skin wounds on the backs of guinea pigs by using a 6 mm punch biopsy, we examined the wound healing effect of topically applied ozonated olive oil (ozone group), as compared to the pure olive oil (oil group) and non-treatment (control group). The ozone group of guinea pig had a significantly smaller wound size and a residual wound area than the oil group, on days 5 (P<0.05) and 7 (P<0.01 and P<0.05) after wound surgery, respectively. Both hematoxylin-eosin staining and Masson-trichrome staining revealed an increased intensity of collagen fibers and a greater number of fibroblasts in the ozone group than that in the oil group on day 7. Immunohistochemical staining demonstrated upregulation of platelet derived growth factor (PDGF), transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF) expressions, but not fibroblast growth factor expression in the ozone group on day 7, as compared with the oil group. In conclusion, these results demonstrate that topical application of ozonated olive oil can accelerate acute cutaneous wound repair in a guinea pig in association with the increased expression of PDGF, TGF-β, and VEGF.

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Author and article information

Journal

Journal ID (publisher-id): KOP

Journal ID (doi): 10.1159/issn.2297-0118

Title: Karger Kompass Ophthalmologie

Publisher: S. Karger AG

ISSN (Print): 2297-0118

ISSN (Electronic): 2297-0045

Publication date Subscription-year: 2019

Publication date (Print): February 2019

Publication date (Electronic): 22 February 2019

Volume: 5

Issue: 1

Pages: 42-48

Affiliations

^aDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rom, Italien; ^bVeterinary Teaching Hospital, School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italien

Author notes

*Leopoldo Spadea, MD, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Via Benozzo Gozzoli 34, 00142 Rom, Italien, leopoldo.spadea@uniroma1.it

Author information

Leopoldo Spadea https://orcid.org/0000-0002-1190-3956

Article

Publisher ID: 496963 Other ID: Karger Kompass Ophthalmol 2019;5:42-48

DOI: 10.1159/000496963

SO-VID: 6eee7569-8429-482a-9a58-b769aed02847

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