An allometric pharmacokinetic model and minimum effective analgesic concentration of fentanyl in patients undergoing major abdominal surgery.

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Abstract

We aimed to characterise the population pharmacokinetics of fentanyl in adults and to determine the minimum effective concentration (MEC) and minimum effective analgesic concentration (MEAC) of i.v. fentanyl in patients after major abdominal open surgery.

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Journal

Journal ID (iso-abbrev): Br J Anaesth

Title: British journal of anaesthesia

Publisher: Elsevier BV

ISSN (Electronic): 1471-6771

ISSN (Print): 0007-0912

Publication date (Electronic): December 2020

Volume: 125

Issue: 6

Affiliations

[1 ] Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.

[2 ] Department of Anesthesiology and Pain Medicine, National Medical Center, Seoul, Republic of Korea.

[3 ] Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

[4 ] Department of Statistics, Ewha Womans University, Seoul, Republic of Korea.

[5 ] Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: byungmoonchoi7@gmail.com.

[6 ] Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Article

Publisher Item ID: S0007-0912(20)30569-9

DOI: 10.1016/j.bja.2020.06.066

PubMed ID: 32861508

SO-VID: 6ef0e047-351f-4e6d-92b9-68fb252f5dd6

History

Keywords: pain,fentanyl,effective,concentration,postoperative pain,pharmacokinetics,pharmacodynamics

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Keywords: pain, fentanyl, effective, concentration, postoperative pain, pharmacokinetics, pharmacodynamics

An allometric pharmacokinetic model and minimum effective analgesic concentration of fentanyl in patients undergoing major abdominal surgery.

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Abstract

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