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      Effects of Acute Behavioral Stress on Plasma and Cerebrospinal Fluid ACTH and β-Endorphin in Rhesus Monkeys

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          To elucidate the effect of acute behavioral stress on plasma and cerebrospinal fluid (CSF) concentrations of adrenocorticotropic hormone (ACTH) and β-endorphin, rhesus monkeys were subjected to 30 min of confinement stress. Simultaneous plasma and. CSF samples revealed no significant change in CSF ACTH or β-endorphin up to 120 min after the onset of the stress despite significant elevations in plasma cortisol, ACTH, and β-endorphin. It is suggested that acute behavioral stress does not alter CSF ACTH or β-endorphin, and that this information may be clinically useful for future human studies of CSF ACTH and β-endorphin in neuropsychiatric illnesses.

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          S. Karger AG
          28 March 2008
          : 40
          : 2
          : 97-101
          aPsychiatry and bGeriatric Sections, William S. Middleton Memorial Veterans Hospital, Madison, Wisc.; cDepartment of Psychiatry and dDepartment of Medicine, University of Wisconsin, Madison, Wisc.; ePsychiatry Section, San Diego Veterans Administration Medical Center, San Diego, Calif.; fDepartment of Psychiatry, University of California at San Diego, La Jolla, Calif., USA
          124061 Neuroendocrinology 1985;40:97–101
          © 1985 S. Karger AG, Basel

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          Pages: 5
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