Effects of Acute Behavioral Stress on Plasma and Cerebrospinal Fluid ACTH and β-Endorphin in Rhesus Monkeys

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Abstract

To elucidate the effect of acute behavioral stress on plasma and cerebrospinal fluid (CSF) concentrations of adrenocorticotropic hormone (ACTH) and β-endorphin, rhesus monkeys were subjected to 30 min of confinement stress. Simultaneous plasma and. CSF samples revealed no significant change in CSF ACTH or β-endorphin up to 120 min after the onset of the stress despite significant elevations in plasma cortisol, ACTH, and β-endorphin. It is suggested that acute behavioral stress does not alter CSF ACTH or β-endorphin, and that this information may be clinically useful for future human studies of CSF ACTH and β-endorphin in neuropsychiatric illnesses.

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Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1985

Publication date (Print): 1985

Publication date (Electronic): 28 March 2008

Volume: 40

Issue: 2

Pages: 97-101

Affiliations

^aPsychiatry and ^bGeriatric Sections, William S. Middleton Memorial Veterans Hospital, Madison, Wisc.; ^cDepartment of Psychiatry and ^dDepartment of Medicine, University of Wisconsin, Madison, Wisc.; ^ePsychiatry Section, San Diego Veterans Administration Medical Center, San Diego, Calif.; ^fDepartment of Psychiatry, University of California at San Diego, La Jolla, Calif., USA

Article

Publisher ID: 124061 Other ID: Neuroendocrinology 1985;40:97–101

DOI: 10.1159/000124061

PubMed ID: 2983257

SO-VID: 6ef5ac55-530c-4aed-8bbc-1b3f7b6c8447

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 04 April 1984

Date accepted : 31 May 1984

Page count

Pages: 5

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