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      Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function.

      1 , , , , ,
      Cell
      Elsevier BV

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          Abstract

          Loss of fragile X mental retardation protein (FMRP) function causes the fragile X mental retardation syndrome. FMRP harbors three RNA binding domains, associates with polysomes, and is thought to regulate mRNA translation and/or localization, but the RNAs to which it binds are unknown. We have used RNA selection to demonstrate that the FMRP RGG box binds intramolecular G quartets. This data allowed us to identify mRNAs encoding proteins involved in synaptic or developmental neurobiology that harbor FMRP binding elements. The majority of these mRNAs have an altered polysome association in fragile X patient cells. These data demonstrate that G quartets serve as physiologically relevant targets for FMRP and identify mRNAs whose dysregulation may underlie human mental retardation.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          0092-8674
          0092-8674
          Nov 16 2001
          : 107
          : 4
          Affiliations
          [1 ] Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, NY 10021, USA.
          Article
          S0092-8674(01)00566-9
          10.1016/s0092-8674(01)00566-9
          11719189
          6f0a4ee7-d8e5-43d2-b695-e60276a02597

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