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Liberal versus restricted fluid resuscitation strategies in trauma patients: a systematic review and meta-analysis of randomized controlled trials and observational studies*.

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      Abstract

      Hemorrhage is responsible for most deaths that occur during the first few hours after trauma. Animal models of trauma have shown that restricting fluid administration can reduce the risk of death; however, studies in patients are difficult to conduct due to logistical and ethical problems. To maximize the value of the existing evidence, we performed a meta-analysis to compare liberal versus restricted fluid resuscitation strategies in trauma patients.

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      Affiliations
      [1 ] 1Department of Emergency Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. 2Department of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. 3Department of Medicine, College of Medicine, Chang-Gung University, Tao-Yuan, Taiwan. 4Department of Medicine, National Defense Medical Center, Taipei, Taiwan. 5Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. 6Department of Emergency Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan. 7Department of Epidemiology, Harvard School of Public Health, Boston, MA.
      Journal
      Crit. Care Med.
      Critical care medicine
      Ovid Technologies (Wolters Kluwer Health)
      1530-0293
      0090-3493
      Apr 2014
      : 42
      : 4
      24335443
      10.1097/CCM.0000000000000050

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