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Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
Jay P Patel
1 ,
Mithat Gönen ,
Maria E Figueroa ,
Hugo Fernandez ,
Zhuoxin Sun ,
Janis Racevskis ,
Pieter Van Vlierberghe ,
Igor Dolgalev ,
Sabrena Thomas ,
Olga Aminova ,
Kety Huberman ,
Janice Cheng ,
Agnes Viale ,
Nicholas D Socci ,
Adriana Heguy ,
Athena Cherry ,
Gail Vance ,
Rodney R Higgins ,
Rhett P Ketterling ,
Robert E Gallagher ,
Mark Litzow ,
Marcel R M van den Brink ,
Hillard M Lazarus ,
Jacob M Rowe ,
Selina Luger ,
Adolfo Ferrando ,
Elisabeth Paietta ,
Martin S Tallman ,
Ari Melnick ,
Omar Abdel-Wahab ,
Ross L Levine
Mar 22 2012
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Abstract
Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not been systematically evaluated in a phase 3 trial of treatment for AML.