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      • Record: found
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      Quality control of Semen Ziziphi Spinosae standard decoction based on determination of multi-components using TOF-MS/MS and UPLC-PDA technology

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          Abstract

          A sensitive, fast and comprehensive method for the quality assessment of Semen Ziziphi Spinosae (SZS) standard decoction with characterization of its chemical components was developed and validated. UPLC-Q/TOF-MS/MS system was used to identify thirty-six chemical components of SZS standard decoction which included nucleosides, phenolic acids, alkaloids, and flavonoids. Furthermore, a UPLC-PDA method was validated to simultaneously determine adenosine, protocatechuic acid, magnoflorine, catechin, protocatechin, vicenin II, spinosin, kaempferol-3-rutinoside, and 6'''-feruloylspinosin which represent four species of characteristic compounds. The qualitative method had been validated according to Chinese Pharmacopoeia (2015 edition) in terms of lineary, repeatability, recovery and stability for all analytes, with the results showing good precision, accuracy and stability. In conclusion, the method using UPLC combined with MS and PDA provided a novel way for the standardization and identification of SZS standard decoction, and also offered a basis for qualitative analysis and quality assessment of the preparations for SZS standard decoction.

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          Chromatographic fingerprint analysis--a rational approach for quality assessment of traditional Chinese herbal medicine.

          Kyle Upton, Zeng Liang, XiangHong Wang … (2006)
          Traditional Chinese Herbal Medicine (TCHM) contain multiple botanicals, each of which contains many compounds that may be relevant to the medicine's putative activity. Therefore, analytical techniques that look at a suite of compounds, including their respective ratios, provide a more rational approach to the authentication and quality assessment of TCHM. In this paper we present several examples of applying chromatographic fingerprint analysis for determining the identity, stability, and consistency of TCHM as well as the identification of adulterants as follows: (1) species authentication of various species of ginseng (Panax ginseng, Panax quinquefolium, Panax noto-ginseng) and stability of ginseng preparations using high performance thin-layer chromatography (HPTLC) fingerprint analysis; (2) batch-to-batch consistency of extracts of Total Glycosides of Peony (TGP), to be used as a raw material and in finished products (TGP powdered extract products), using high performance liquid chromatography (HPLC) fingerprint analysis with a pattern recognition software interface (CASE); (3) documenting the representative HPLC fingerprints of Immature Fruits of Terminalia chebula (IFTC) through the assessment of raw material, in-process assay of the extracts, and the analysis of the finished product (tablets); (4) HPLC fingerprint study demonstrating the consistent quality of total flavonoids of commercial extracts of ginkgo (Ginkgo biloba) leaves (EGb) along with detection of adulterations. The experimental conditions as well as general comments on the application of chromatographic fingerprint analysis are discussed.
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            Hypnotic effect of jujubosides from Semen Ziziphi Spinosae.

            Jie-Xin Cao, Qing-Ying Zhang, Su-Ying Cui … (2010)
            Semen Ziziphi Spinosae, the seed of Ziziphus jujuba Mill. var. spinosa (bunge) Hu ex H.F. Chow has been widely used in treating insomnia and anxiety.
            Article 0 comments Cited 49 times – based on 0 reviews     Review now
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              Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen Ziziphus jujube.

              Juan Huang, Jian Chen, Jian Jiang … (2007)
              Semen Ziziphus jujube (SZJ), the seeds of Ziziphus jujuba Mill. var. spinosa, is a kind of traditional Chinese medicine used for its action on insomnia. In order to analyze the effective component, we investigated and compared the sedative and hypnotic effects of three kinds of compounds, flavonoids, saponins, and polysaccharides. Flavonoids, saponins, and polysaccharides were extracted from SZJ and orally administered to mice separately at 17 g kg(-1) per day for certain days before animal tests. Spontaneous motility and coordinated movement tests were used to observe the effects of the three kinds of compounds on the mouse behavior, and sodium barbital-induced sleeping time of mouse were tested to analyze the effects of the three kinds of compounds on the sleep of mouse. Results show that flavonoids and saponins caused a significant reduction of walking time and coordinated movement ability of mouse, significantly prolonged its sleeping time at 40 mg kg(-1), ip, subthreshold dose and increased the sleeping number of animals at 50 mg kg(-1), ip, superthreshold dose induced by coeliac injection of sodium barbital. Polysaccharides did not show any significance in all animal tests. Comparative analysis showed that saponins had a more effective sedative and hypnotic function than that of flavonoids, polysaccharides did not show a sedative and hypnotic effect.
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                Author and article information

                Contributors
                Kaishun Bi
                Journal
                Journal ID (nlm-ta): J Pharm Anal
                Journal ID (iso-abbrev): J Pharm Anal
                Title: Journal of Pharmaceutical Analysis
                Publisher: Xi'an Jiaotong University
                ISSN (Print): 2095-1779
                ISSN (Electronic): 2214-0883
                Publication date PMC-release: 02 January 2019
                Publication date (Print): December 2019
                Publication date (Electronic): 02 January 2019
                Volume: 9
                Issue: 6
                Pages: 406-413
                Affiliations
                [a ]School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
                [b ]National and Local United Engineering Laboratory for Key Technology of Chinese Material Medical Quality Control, Shenyang Pharmaceutical University, Shenyang 110016, China
                Author notes
                [* ]Corresponding author at: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. kaishunbi.syphu@ 123456gmail.com
                Article
                Publisher ID: S2095-1779(18)30088-1
                DOI: 10.1016/j.jpha.2019.01.001
                PMC ID: 6931073
                PubMed ID: 31890340
                SO-VID: 6f2a36d7-4941-442e-981c-f35825ef035c
                Copyright © © 2019 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 9 June 2018
                Date revision received : 30 December 2018
                Date accepted : 2 January 2019
                Categories
                Subject: Original Article

                Keywords: identification,semen ziziphi spinosae (szs),standard decoction,quality assessment,uplc,tof-ms/ms
                Data availability:
                Keywords: identification, semen ziziphi spinosae (szs), standard decoction, quality assessment, uplc, tof-ms/ms

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