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      IL-6 in Inflammation, Immunity, and Disease

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          Abstract

          Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. Although its expression is strictly controlled by transcriptional and posttranscriptional mechanisms, dysregulated continual synthesis of IL-6 plays a pathological effect on chronic inflammation and autoimmunity. For this reason, tocilizumab, a humanized anti-IL-6 receptor antibody was developed. Various clinical trials have since shown the exceptional efficacy of tocilizumab, which resulted in its approval for the treatment of rheumatoid arthritis and juvenile idiopathic arthritis. Moreover, tocilizumab is expected to be effective for other intractable immune-mediated diseases. In this context, the mechanism for the continual synthesis of IL-6 needs to be elucidated to facilitate the development of more specific therapeutic approaches and analysis of the pathogenesis of specific diseases.

          Abstract

          Various immune diseases (e.g., rheumatoid arthritis) involve the dysregulated, continual synthesis of interleukin 6 (IL-6). They can be treated by targeting IL-6 with tocilizumab, but more specific therapies are needed.

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          Author and article information

          Journal
          Cold Spring Harb Perspect Biol
          Cold Spring Harb Perspect Biol
          cshperspect
          cshperspect
          Cold Spring Harbor Perspectives in Biology
          Cold Spring Harbor Laboratory Press
          1943-0264
          October 2014
          : 6
          : 10
          Affiliations
          [1 ]Department of Clinical Application of Biologics, Osaka University Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
          [2 ]Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan
          [3 ]Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
          [4 ]Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan
          Author notes
          Article
          PMC4176007 PMC4176007 4176007 a016295
          10.1101/cshperspect.a016295
          4176007
          25190079
          Copyright © 2014 Cold Spring Harbor Laboratory Press; all rights reserved
          Page count
          Pages: 16
          Categories
          084
          Perspectives
          Immunology

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