1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Ready, set, go

      Nature Reviews Neuroscience
      Springer Science and Business Media LLC

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references1

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

          Summary Motor behaviors are often planned long before execution, but only released after specific sensory events. Planning and execution are each associated with distinct patterns of motor cortex activity. Key questions are how these dynamic activity patterns are generated and how they relate to behavior. Here we investigate the multi-regional neural circuits that link an auditory ‘go cue’ and the transition from planning to execution of directional licking. Ascending glutamatergic neurons in the midbrain reticular and pedunculopontine nuclei show short-latency and phasic changes in spike rate that are selective for the go cue. This signal is transmitted via the thalamus to the motor cortex, where it triggers a rapid reorganization of motor cortex state from planning-related activity to a motor command, which in turn drives appropriate movement. Our studies show how midbrain can control cortical dynamics via the thalamus for rapid and precise motor behavior.
            Bookmark

            Author and article information

            Journal
            Nature Reviews Neuroscience
            Nat Rev Neurosci
            Springer Science and Business Media LLC
            1471-003X
            1471-0048
            March 25 2022
            Article
            10.1038/s41583-022-00586-5
            6f397a4a-586b-4886-8069-000d20886563
            © 2022

            https://www.springer.com/tdm

            https://www.springer.com/tdm

            History

            Comments

            Comment on this article