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      Is gonadotropin-releasing hormone agonist usage really leading to thyroid dysfunction?

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          Abstract

          Objectives

          Gonadotropin-releasing hormone agonist (GnRHa) could influence the levels of sex hormones and thyroid hormones. The aim of this study was to investigate the effect of GnRHa on thyroid function.

          Materials and methods

          The data of the patients were collected from the registrations of July 2014–October 2014. A total of 41 women who underwent one-time IVF cyclus were evaluated in this cross-sectional study. The patients were categorized into two groups according to the serum T 3, T 4, and TSH levels before and 2 weeks’ after the administration of GnRHa.

          Results

          Mean basal TSH and mean TSH levels on hCG day were 1.98 ± 0.77 and 1.75 ± 0.70, respectively. The difference between the two groups was statistically significant ( p < 0.05). GnRHa did not lead to statistically significant difference on serum-free T 3 and T 4 levels.

          Conclusions

          In conclusion, our results demonstrate that GnRHa led to a decrease on serum TSH level. Serum-free T 3 and T 4 levels were remained unchanged and this might be due to early measurement of the hormone levels (just 2 weeks later from GnRHa administration).

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          Author and article information

          Journal
          imas
          1646
          Interventional Medicine and Applied Science
          IMAS
          Akadémiai Kiadó (Budapest )
          2061-1617
          2061-5094
          11 November 2019
          :
          :
          : 1-3
          Affiliations
          [ 1 ]Department of Obstetrics and Gynecology, Zekai Tahir Burak Women’s Health Education and Research Hospital , Ankara, Turkey
          [ 2 ]Department of Obstetrics and Gynecology, School of Medicine, Bozok University , Yozgat, Turkey
          Author notes
          [* ]Corresponding author: Mustafa Kara; Department of Obstetrics and Gynecology, School of Medicine, Bozok University, Adnan Menderes Boulevard No. 44, 66200 Yozgat, Turkey; Phone: +90 354 212 70 01; Fax: +90 354 212 27 89; GSM: +90 533 622 65 01; E-mails: mustafa.kara@ 123456bozok.edu.tr ; m.kara66@ 123456hotmail.com
          Article
          10.1556/1646.10.2018.32
          6f3e5e28-f733-4606-8a6b-c1614b7d9270
          © 2018 The Author(s)

          This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.

          Page count
          Figures: 0, Tables: 2, Equations: 0, References: 11, Pages: 3
          Funding
          Funding sources: None.
          Categories
          ORIGINAL PAPER

          Medicine,Immunology,Health & Social care,Microbiology & Virology,Infectious disease & Microbiology
          thyroid hormones,GnRHa,IVF–ICSI,gonadotropin,infertility

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