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      How many drug targets are there?

      Nature reviews. Drug discovery
      Drug Approval, Drug Delivery Systems, trends, Drug Design, Drugs, Investigational, therapeutic use, Genome, Human, Humans, Technology, Pharmaceutical

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          Abstract

          For the past decade, the number of molecular targets for approved drugs has been debated. Here, we reconcile apparently contradictory previous reports into a comprehensive survey, and propose a consensus number of current drug targets for all classes of approved therapeutic drugs. One striking feature is the relatively constant historical rate of target innovation (the rate at which drugs against new targets are launched); however, the rate of developing drugs against new families is significantly lower. The recent approval of drugs that target protein kinases highlights two additional trends: an emerging realization of the importance of polypharmacology, and also the power of a gene-family-led approach in generating novel and important therapies.

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          Author and article information

          Journal
          17139284
          10.1038/nrd2199

          Chemistry
          Drug Approval,Drug Delivery Systems,trends,Drug Design,Drugs, Investigational,therapeutic use,Genome, Human,Humans,Technology, Pharmaceutical

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