Blog
About

57
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.

      Proceedings of the National Academy of Sciences of the United States of America

      chemistry, Secretin, Rats, Wistar, Rats, genetics, Protein Precursors, physiology, Neurotransmitter Agents, Neuropeptides, Neurons, Molecular Sequence Data, Mice, Male, Intracellular Signaling Peptides and Proteins, Hypothalamus, Posterior, Homeostasis, Consensus Sequence, Chromosomes, Carrier Proteins, Base Sequence, Animals, Amino Acid Sequence, Synaptic Vesicles

      Read this article at

      ScienceOpenPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          We describe a hypothalamus-specific mRNA that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin. The hypocretin (Hcrt) protein products are restricted to neuronal cell bodies of the dorsal and lateral hypothalamic areas. The fibers of these neurons are widespread throughout the posterior hypothalamus and project to multiple targets in other areas, including brainstem and thalamus. Hcrt immunoreactivity is associated with large granular vesicles at synapses. One of the Hcrt peptides was excitatory when applied to cultured, synaptically coupled hypothalamic neurons, but not hippocampal neurons. These observations suggest that the hypocretins function within the CNS as neurotransmitters.

          Related collections

          Author and article information

          Journal
          18213
          9419374

          Comments

          Comment on this article