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      The neuronal background K2P channels: focus on TREK1.

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      Nature reviews. Neuroscience
      Springer Science and Business Media LLC

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          Abstract

          Two-pore-domain K(+) (K(2P)) channel subunits are made up of four transmembrane segments and two pore-forming domains that are arranged in tandem and function as either homo- or heterodimeric channels. This structural motif is associated with unusual gating properties, including background channel activity and sensitivity to membrane stretch. Moreover, K(2P) channels are modulated by a variety of cellular lipids and pharmacological agents, including polyunsaturated fatty acids and volatile general anaesthetics. Recent in vivo studies have demonstrated that TREK1, the most thoroughly studied K(2P) channel, has a key role in the cellular mechanisms of neuroprotection, anaesthesia, pain and depression.

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          Author and article information

          Journal
          Nat Rev Neurosci
          Nature reviews. Neuroscience
          Springer Science and Business Media LLC
          1471-003X
          1471-003X
          Apr 2007
          : 8
          : 4
          Affiliations
          [1 ] Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 6097, Université de Nice-Sophia Antipolis, 660 route des Lucioles, 06560 Valbonne, France. honore@ipmc.cnrs.fr
          Article
          nrn2117
          10.1038/nrn2117
          17375039
          6f758132-f984-441d-a4c9-79995fd8a32c

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