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      A brief history of artemisinin: Modes of action and mechanisms of resistance

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          Abstract

          The cornerstone of antimalarial treatment, artemisinin, has reduced malaria associated morbidity and mortality worldwide. However, Plasmodium falciparum parasites with reduced sensitivity to artemisinin have emerged, and this threatens malaria control and elimination efforts. In this minireview, we describe the initial development of artemisinin as an antimalarial drug, its use both historically and currently, and our current understanding of its mode of action and the mechanisms by which malaria parasites achieve resistance.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 May 2019
          : 17
          : 5
          : 331-336
          Affiliations
          1 Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225009, China
          2 Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China
          3 Jiangsu Key laboratory of integrated traditional Chinese and Western Medicine for prevention and treatment of Senile Diseases, Yangzhou University, Yangzhou 225009, China
          4 Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
          5Malaria Unit, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, Japan
          6Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China
          7Public Health Research Center, Jiangnan University, Wuxi 214122, China
          Author notes
          *Corresponding authors: CAO Jun, Tel: 86-510-68781007, E-mail: caojuncn@ 123456hotmail.com ; Richard Culleton, E-mail: richard@ 123456nagasakiu.ac.jp

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30038-X
          10.1016/S1875-5364(19)30038-X
          31171267
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81601790
          Award ID: 81603080
          Funded by: Natural Science Foundation of Jiangsu Province
          Award ID: BK20150001
          Funded by: Jiangsu Provincial Department of Science and Technology
          Award ID: BE2016631
          Award ID: BM2018020)
          Funded by: Jiangsu Provincial Project of Invigorating Health Care through Science, Technology and Education
          Award ID: CXTDA2017031
          Award ID: wk018-004
          This work was supported by the National Natural Science Foundation of China (Nos. 81601790 and 81603080), the Natural Science Foundation of Jiangsu Province (No. BK20150001), the Jiangsu Provincial Department of Science and Technology (Nos. BE2016631 and BM2018020), and the Jiangsu Provincial Project of Invigorating Health Care through Science, Technology and Education (Nos. CXTDA2017031 and wk018-004).

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