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      Bibliometric Analysis of Literature Published on Antibacterial Dental Adhesive from 1996–2020

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          Abstract

          This study aimed to investigate the current state of research on antibacterial dental adhesives. The interest in this field can be drawn from an increasing number of scholarly works in this area. However, there is still a lack of quantitative measurement of this topic. The main aim of this study was to consolidate the research published on the antibacterial adhesive from 1996 to 2020 in Web of Science indexed journals. The bibliometric method, a quantitative study of investigating publishing trends and patterns, was used for this study. The result has shown that a gradual increase in research was found, whereby a substantial increase was observed from 2013. A total of 248 documents were published in 84 journals with total citations of 5107. The highly cited articles were published mainly in Q1 category journals. Most of the published articles were from the USA, China, and other developed countries; however, some developing countries contributed as well. The authorship pattern showed an interdisciplinary and collaborative approach among researchers. The thematic evaluation of keywords along with a three-factor analysis showed that ‘antibacterial adhesives’ and ‘quaternary ammonium’ have been used commonly. This bibliometric analysis can provide direction not only to researchers but also to funding organizations and policymakers.

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          Most cited references284

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          Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans.

          The antibacterial activity of quaternary ammonium polyethylenimine (PEI) nanoparticles embedded at 1%w/w with clinically used bonding, flowable and hybrid dental composite resins and cured by light polymerization was studied. The antibacterial activity was tested with Streptoccocus mutans by: (i) the agar diffusion test (ADT); (ii) the direct contact test; (iii) bacterial growth in the materials elute; (iv) and scanning electron microscope (SEM). Using the direct contact test, antibacterial activity (p<0.001) was found in all three types of composite resins incorporated with the synthesized nanoparticles. The effect lasted for at least 1 month. SEM demonstrated bacterial debris and no streptococcal chains at 24h of bacterial contact. The addition of 1%w/w of nanoparticles did not affect the flexural modulus and the flexural strength of the dental composite materials. The results indicate that quaternary ammonium PEI nanoparticles immobilized in resin-based materials have a strong antibacterial activity upon contact without leach-out of the nanoparticles and without compromise in mechanical properties.
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            Classification review of dental adhesive systems: from the IV generation to the universal type

            Adhesive dentistry has undergone great progress in the last decades. In light of minimal-invasive dentistry, this new approach promotes a more conservative cavity design, which relies on the effectiveness of current enamel-dentine adhesives. Adhesive dentistry began in 1955 by Buonocore on the benefits of acid etching. With changing technologies, dental adhesives have evolved from no-etch to total-etch (4th and 5th generation) to self-etch (6th, 7th and 8th generation) systems. Currently, bonding to dental substrates is based on three different strategies: 1) etch-and-rinse, 2) self-etch and 3) resin-modified glass-ionomer approach as possessing the unique properties of self-adherence to the tooth tissue. More recently, a new family of dentin adhesives has been introduced (universal or multi-mode adhesives), which may be used either as etch-and-rinse or as self-etch adhesives. The purpose of this article is to review the literature on the current knowledge for each adhesive system according to their classification that have been advocated by many authorities in most operative/restorative procedures. As noted by several valuable studies that have contributed to understanding of bonding to various substrates helps clinicians to choose the appropriate dentin bonding agents for optimal clinical outcomes.
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              Experimental antimicrobial orthodontic adhesives using nanofillers and silver nanoparticles.

              Experimental composite adhesives (ECAs) containing silica nanofillers and silver nanoparticles were compared with two conventional adhesives (composite and resin-modified glass ionomer [RMGI]) to analyze surface characteristics, physical properties and antibacterial activities against cariogenic streptococci. Surface roughness and surface free energy (SFE) characteristics were measured using confocal laser scanning microscopy and the sessile drop method. Shear bond strength and bond failure interface were analyzed to compare the physical properties. Antimicrobial activities were analyzed by a bacterial adhesion assay, a disk diffusion test, and an optical density measurement of bacterial suspension containing each adhesive. ECAs had rougher surfaces than conventional adhesives due to the addition of silver nanoparticles. ECAs had more similar SFE characteristics to composite than to RMGI. Bacterial adhesion to ECAs was less than to conventional adhesives, which was not influenced by saliva coating. Bacterial suspension containing ECAs showed slower bacterial growth than those containing conventional adhesives. There was no significant difference in shear bond strength and bond failure interface between ECAs and conventional adhesives. This study suggests that ECAs can help prevent enamel demineralization around their surfaces without compromising physical properties.

                Author and article information

                Journal
                Polymers (Basel)
                Polymers (Basel)
                polymers
                Polymers
                MDPI
                2073-4360
                29 November 2020
                December 2020
                : 12
                : 12
                : 2848
                Affiliations
                [1 ]Department of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia; ykalmaimouni@ 123456iau.edu.sa
                [2 ]Deanship of Library Affairs, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia; suRehman@ 123456iau.edu.sa
                [3 ]Central Library, Prince Sultan University, Riyadh 11586, Saudi Arabia; shakil@ 123456psu.edu.sa
                [4 ]Department of Oral Biology, University of Health Sciences, Lahore 54000, Pakistan; mariakhan1685@ 123456gmail.com
                [5 ]Islamabad Model College for Boys, H-9, Islamabad 44000, Pakistan; gmurtazaashiq00@ 123456gmail.com
                Author notes
                [* ]Correspondence: akhan@ 123456iau.edu.sa ; Tel.: +966-594-781-075
                Author information
                https://orcid.org/0000-0002-2165-800X
                https://orcid.org/0000-0002-8169-0132
                https://orcid.org/0000-0002-8812-4205
                https://orcid.org/0000-0001-7775-4917
                Article
                polymers-12-02848
                10.3390/polym12122848
                7761276
                33260410
                6f9e864a-76b4-4c8d-ba57-b5b4148ebb0d
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 07 November 2020
                : 26 November 2020
                Categories
                Review

                dental adhesives,antibacterial adhesives,bonding agents,bibliometric analysis,mapping review,web of science,healthcare

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