37
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Molecular interaction map of the mammalian cell cycle control and DNA repair systems.

      1
      Molecular biology of the cell
      American Society for Cell Biology (ASCB)

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Eventually to understand the integrated function of the cell cycle regulatory network, we must organize the known interactions in the form of a diagram, map, and/or database. A diagram convention was designed capable of unambiguous representation of networks containing multiprotein complexes, protein modifications, and enzymes that are substrates of other enzymes. To facilitate linkage to a database, each molecular species is symbolically represented only once in each diagram. Molecular species can be located on the map by means of indexed grid coordinates. Each interaction is referenced to an annotation list where pertinent information and references can be found. Parts of the network are grouped into functional subsystems. The map shows how multiprotein complexes could assemble and function at gene promoter sites and at sites of DNA damage. It also portrays the richness of connections between the p53-Mdm2 subsystem and other parts of the network.

          Related collections

          Author and article information

          Journal
          Mol Biol Cell
          Molecular biology of the cell
          American Society for Cell Biology (ASCB)
          1059-1524
          1059-1524
          Aug 1999
          : 10
          : 8
          Affiliations
          [1 ] Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, Bethesda, Maryland 20892, USA. kohnk@dc37a.nci.nih.gov
          Article
          10.1091/mbc.10.8.2703
          25504
          10436023
          6fa8367f-e0c7-4623-8b26-db82351cffe5
          History

          Comments

          Comment on this article