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      Na +/H + Exchange in Patients with Mild Chronic Renal Failure

      , ,

      Nephron

      S. Karger AG

      Na+/H+ exchange, Chronic renal failure, Lymphocytes

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          Abstract

          Cytosolic pH (pH<sub>i</sub>) and Na<sup>+</sup>/H<sup>+</sup> exchange activity were measured in lymphocytes from 22 patients with mild chronic renal failure, and 21 age- and sex-matched normotensive healthy control subjects using the fluorescent dye technique. The basal pH<sub>i</sub> in resting lymphocytes was not significantly different in both groups tested (control, pH<sub>i</sub> 7.18 ± 0.04; patients with mild chronic renal failure, 7.17 ± 0.05). The initial rate of pH<sub>i</sub> recovery immediately after intra-cellular acidification with 100 mmol/l propionic acid, representing the maximum Na<sup>+</sup>/H<sup>+</sup> exchange activity, was significantly higher in lymphocytes from patients with mild chronic renal failure (7.10 ± 0.52 dpHi/s, mean ± SEM) when compared with control subjects (5.42 ± 0.47 dpH<sub>i</sub>/s; p < 0.05). No significant correlation between Na<sup>+</sup>/H<sup>+</sup> exchange activity and blood pressure could be obtained in patients with mild chronic renal failure. Furthermore, there was no relationship of Na<sup>+</sup>/H<sup>+</sup> exchange activity to cytosolic pH or extracellular pH. It is concluded that an enhanced Na<sup>+</sup>/H<sup>+</sup> exchange activity can be detected in patients with mild chronic renal failure and may not be related to the significant abnormalities of electrolyte and acid-base metabolism commonly observed in patients with end-stage renal failure or on hemodialysis.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1996
          1996
          24 December 2008
          : 74
          : 1
          : 114-119
          Affiliations
          Medizinische Universitäts-Poliklinik, University of Münster, Germany
          Article
          189289 Nephron 1996;74:114-119
          10.1159/000189289
          8883028
          © 1996 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Lymphocytes, Na+/H+ exchange, Chronic renal failure

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