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      Electroanalysis of dopamine at a gold electrode modified with N-acetylcysteine self-assembled monolayer.

      1 , ,

      Talanta

      Elsevier BV

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          Abstract

          Voltammetric behavior of dopamine (DA) on a gold electrode modified with the self-assembled monolayer (SAM) of N-acetylcysteine has been investigated, and one pair of well-defined redox peaks of dopamine is obtained at the SAM modified gold electrode. The oxidation peak current increases linearly with the concentration of dopamine in the range of 1.0x10 (-6)to 2.0x10 (-4)moll(-1). The detection limit is 8.0x10(-7)moll(-1). This method will be applicable to the determination of dopamine in injection of dopamine hydrochloride, and the good recovery of dopamine is obtained. Furthermore, The SAM modified gold electrode can resolve well the voltammetric responses of dopamine and ascorbic acid (AA), so it can also be applied to the determination of dopamine in the presence of ascorbic acid.

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          Author and article information

          Journal
          Talanta
          Talanta
          Elsevier BV
          1873-3573
          0039-9140
          Jul 08 2004
          : 63
          : 4
          Affiliations
          [1 ] Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China.
          S0039-9140(04)00039-6
          10.1016/j.talanta.2004.01.019
          18969533

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