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      Vitamin D toxicity related to its physiological and unphysiological supply.

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          Abstract

          Vitamin D is defined as a nutrient despite its rare occurrence in food. Vitamin D status is determined mainly by solar UV light action in skin. However, the strategy to combat vitamin D deficiency has been to increase oral intake of vitamin D in greater amounts than could be obtained from food. Persistent large intakes of vitamin D can cause hypercalcaemic toxicity. Although the amounts recommended to prevent deficiency are far less than those causing such toxicity, the possibility of other toxic actions from increased intake of vitamin D has been ignored. Animal experiments have demonstrated that moderate amounts of oral vitamin D over time result in atherosclerosis. Differences in the fate of vitamin D could explain this angiotoxicity.

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          Author and article information

          Journal
          Trends Endocrinol Metab
          Trends in endocrinology and metabolism: TEM
          Elsevier BV
          1879-3061
          1043-2760
          Nov 2021
          : 32
          : 11
          Affiliations
          [1 ] Sydney School of Veterinary Science, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: david.fraser@sydney.edu.au.
          Article
          S1043-2760(21)00199-5
          10.1016/j.tem.2021.08.006
          34518055
          6fde0f53-344f-4f11-8948-baf54aae6b18
          History

          animal experiments,oral vitamin D toxicity,atherosclerosis

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