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      Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy

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          Abstract

          Hyaluronic acid functionalized gold nanorods with loading of copper complexes show a unique release manner and synergetic antitumor efficacy.

          Abstract

          We herein report a hybrid nanocomposite (AuNRs-CTN@THA) which is based on hyaluronic acid-coated gold nanorods with loading of a copper complex through strong bonds. AuNRs-CTN@THA exhibits durable photothermal conversion capacity for pH-dominant and pH/temperature dual sensitive drug release, accomplishing synergetic antitumor efficacy and deep tumor penetration.

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          Author and article information

          Contributors
          Journal
          JMCBDV
          Journal of Materials Chemistry B
          J. Mater. Chem. B
          Royal Society of Chemistry (RSC)
          2050-750X
          2050-7518
          June 10 2020
          2020
          : 8
          : 22
          : 4841-4845
          Affiliations
          [1 ]Jiangsu Key Laboratory for Functional Substance of Chinese Medicine
          [2 ]Nanjing University of Chinese Medicine
          [3 ]Nanjing 210023
          [4 ]P. R. China
          [5 ]Jiangsu Engineering Research Center for Efficient Delivery System of TCM
          [6 ]State Key Laboratory of Coordination Chemistry
          [7 ]School of Chemistry and Chemical Engineering, Nanjing University
          Article
          10.1039/D0TB00097C
          6fe955c3-13a8-4fd3-88df-e36cccfed12e
          © 2020

          http://rsc.li/journals-terms-of-use

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