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      Recent advances in quantitative LA-ICP-MS analysis: challenges and solutions in the life sciences and environmental chemistry

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          Abstract

          Laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) is a widely accepted method for direct sampling of solid materials for trace elemental analysis. The number of reported applications is high and the application range is broad; besides geochemistry, LA-ICP-MS is mostly used in environmental chemistry and the life sciences. This review focuses on the application of LA-ICP-MS for quantification of trace elements in environmental, biological, and medical samples. The fundamental problems of LA-ICP-MS, such as sample-dependent ablation behavior and elemental fractionation, can be even more pronounced in environmental and life science applications as a result of the large variety of sample types and conditions. Besides variations in composition, the range of available sample states is highly diverse, including powders (e.g., soil samples, fly ash), hard tissues (e.g., bones, teeth), soft tissues (e.g., plants, tissue thin-cuts), or liquid samples (e.g., whole blood). Within this article, quantification approaches that have been proposed in the past are critically discussed and compared regarding the results obtained in the applications described. Although a large variety of sample types is discussed within this article, the quantification approaches used are similar for many analytical questions and have only been adapted to the specific questions. Nevertheless, none of them has proven to be a universally applicable method.

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          High resolution analysis of trace elements in corals by laser ablation ICP-MS

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            Two-dimensional gel electrophoresis in proteomics: Past, present and future.

            Two-dimensional gel electrophoresis has been instrumental in the birth and developments of proteomics, although it is no longer the exclusive separation tool used in the field of proteomics. In this review, a historical perspective is made, starting from the days where two-dimensional gels were used and the word proteomics did not even exist. The events that have led to the birth of proteomics are also recalled, ending with a description of the now well-known limitations of two-dimensional gels in proteomics. However, the often-underestimated advantages of two-dimensional gels are also underlined, leading to a description of how and when to use two-dimensional gels for the best in a proteomics approach. Taking support of these advantages (robustness, resolution, and ability to separate entire, intact proteins), possible future applications of this technique in proteomics are also mentioned. Copyright © 2010 Elsevier B.V. All rights reserved.
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              Laser ablation in analytical chemistry-a review.

              Laser ablation is becoming a dominant technology for direct solid sampling in analytical chemistry. Laser ablation refers to the process in which an intense burst of energy delivered by a short laser pulse is used to sample (remove a portion of) a material. The advantages of laser ablation chemical analysis include direct characterization of solids, no chemical procedures for dissolution, reduced risk of contamination or sample loss, analysis of very small samples not separable for solution analysis, and determination of spatial distributions of elemental composition. This review describes recent research to understand and utilize laser ablation for direct solid sampling, with emphasis on sample introduction to an inductively coupled plasma (ICP). Current research related to contemporary experimental systems, calibration and optimization, and fractionation is discussed, with a summary of applications in several areas.
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                Author and article information

                Contributors
                a.limbeck@tuwien.ac.at
                Journal
                Anal Bioanal Chem
                Anal Bioanal Chem
                Analytical and Bioanalytical Chemistry
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                1618-2642
                1618-2650
                14 July 2015
                14 July 2015
                2015
                : 407
                : 22
                : 6593-6617
                Affiliations
                [ ]Institute of Chemical Technologies and Analytics, Division of Instrumental Analytical Chemistry, TU Wien, Getreidemarkt 9/164, 1060 Vienna, Austria
                [ ]Elkem AS, Technology, Central Analytical Laboratory, Fiskaaveien 100, P.O. Box 8040, Vaagsbygd, 4675 Kristiansand Norway
                [ ]Department of Analytical Chemistry, Ghent University, Krijgslaan 281 - S12, 9000 Ghent, Belgium
                Article
                8858
                10.1007/s00216-015-8858-0
                4545187
                26168964
                6ff1b5e0-5d22-438a-a7b2-c9072bcc3876
                © The Author(s) 2015

                Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                History
                : 26 March 2015
                : 9 June 2015
                : 15 June 2015
                Categories
                Review
                Custom metadata
                © Springer-Verlag Berlin Heidelberg 2015

                Analytical chemistry
                la-icp-ms,quantitative analysis,certified reference material,matrix-matched standards,internal standard correction,liquid standards

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