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      Long-term changes in gene expression in fetal alcohol spectrum disorders

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      Disease Models & Mechanisms
      The Company of Biologists Limited

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          Abstract

          Consumption of alcohol during pregnancy is associated with a variety of birth defects. Alcohol-related birth defects are collectively known as fetal alcohol spectrum disorders (FASDs), which are a leading cause of cognitive defects in North America. Studies using animal models have shown that alcohol induces global changes in gene expression in the developing brain. Using an FASD mouse model that they previously established, Shiva Singh and colleagues tested the hypothesis that long-term alterations in gene expression, mediated by epigenetic mechanisms, are a feature of FASDs. Developing mice were exposed to alcohol and, as adults, their epigenomes were assessed for changes in DNA methylation patterns and non-coding RNA (ncRNA) expression. The analysis unveiled long-lasting alterations in DNA methylation in response to fetal alcohol exposure. These changes mapped to the promoters of certain ncRNAs, implicating ncRNA deregulation in FASDs. Page 977

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          Author and article information

          Journal
          Dis Model Mech
          Dis Model Mech
          dmm
          DMM
          Disease Models & Mechanisms
          The Company of Biologists Limited
          1754-8403
          1754-8411
          July 2013
          : 6
          : 4
          : 867
          Article
          0060867e
          3701203
          6ff7c2fd-4b1a-4fd2-a01c-2f4700c2e585
          Written by editorial staff. © 2013. Published by The Company of Biologists Ltd.

          This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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          July 2013

          Molecular medicine
          Molecular medicine

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