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      Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses.

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          Abstract

          Seven arenaviruses cause viral hemorrhagic fever in humans: the Old World arenaviruses Lassa and Lujo, and the New World Clade B arenaviruses Machupo (MACV), Junín (JUNV), Guanarito (GTOV), Sabiá (SABV), and Chapare (CHPV). All of these viruses are Risk Group 4 biosafety pathogens. MACV causes human disease outbreak with high case-fatality rates. To date, at least 1,200 cases with ≈200 fatalities have been recorded.

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          Author and article information

          Journal
          Expert Opin Drug Discov
          Expert opinion on drug discovery
          Informa Healthcare
          1746-045X
          1746-0441
          Jul 2012
          : 7
          : 7
          Affiliations
          [1 ] United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
          Article
          NIHMS398718
          10.1517/17460441.2012.687719
          3426302
          22607481
          702d2f07-7825-4d6c-a18e-6ffdceffa0a4

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